- Simons, Keating2
- Simpson, William2
- Sims, John, 1790-18682
- Singletary, John J.2
- Sinkler, Charles2
- Slater, Thomas2
- Sloan, John T.2
- Smart, W.G.2
- Smith, Sarah2
- Smithy, Horace Gilbert, 1914-19482
- South Carolina Library Association2
- South Carolina State Museum2
- South Carolina. State Election Commission2
- Souvenir Post Card Company2
- Spencer, Harold 2
- Spilsbury, John, 1739-1769 (cartographer) (engraver)2
- St. John, Francis R.2
- Stacker & Hill2
- Steedman, Charles John, 1783-18382
- Steele, George2