- Renwick, William1
- Roberts, Ben6
- Roberts, Carlisle (photographer)6
- Robinson, J. M.1
- Rutherford, Sallie Fair, 1842-19211
- Sanborn Fire Insurance Map Company7
- Savage, Mattie, 1922- (interviewee)1
- Shand, Gadsden E.1
- Sims, Jimmie, 1922-2011 (interviewee)1
- South Carolina Baptist Convention2
- South Carolina Department of Parks, Recreation and Tourism242
- South Carolina Department of Transportation15
- South Carolina State Library Board1
- South Carolina. State Commission of Forestry872
- Tanner, Henry Schenck, 1786-1858 (Engraver)1
- Thomas, John P.1
- Thompson, Harold, 1951- (interviewee)1
- Thompson, R. (Surveyor)1
- Thorn, Susan Rebecca5
- Topography by W.L. Miller1