- McLeod Family Papers, 1873-1990 (bulk 1900-1965)1
- Midlands Memories7
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19204
- Muriel and Marcus Zbar Collection1
- Parish Records11
- Paul Craven, Jr. Collection10
- Poe Mill3
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library4
- Robert B. Ariail Collection of Historical Astronomy2
- Russell Maxey Photograph Collection9
- Sarah Campbell Allan, M.D. Papers 1895-19521
- Shakespeare First Folio Teaching Resources1
- South Carolina Baptist Church Records75
- South Carolina Fall Line Collection2
- South Carolina Postcards3
- South Caroliniana Cookbook Collection1
- South Caroliniana Library Map Collection10
- St. Paul's Episcopal Church records, 1819-19711
- Stereoscopic Photographs1
- The Hospital Herald, 1899-19001