- Drayton Papers, 1701-200424
- Esau Jenkins Papers, 1963-200323
- Joseph E. Winter Photograph Collection21
- Philip Simmons Collection21
- Roman Vishniac: The Subject is Nature21
- Harry Blas and Erika Stockfleth Blas Papers, circa 1910-circa 198020
- Pincus Kolender Papers, circa 1915-199620
- Roy S. MacElwee Collection20
- Shadows of the Gullah Geechee20
- Charles Cross Collection of Buchenwald Concentration Camp Photographs, 194518
- Cohen, Emanuel, Moses, Seixas Family Papers18
- Fritz Hollings: In His Own Words18
- Armstrong Family Papers, 1900-193017
- Metchicas and Kehayas Family Letters17
- Edmondston-Alston Family Letters and Paper Materials, 1782-191916
- Grimke family papers, 1678-197716
- St. Paul's Episcopal Church records, 1819-197116
- Womans College of Due West Photograph Collection15
- Camilla Urso Collection13
- Joe Engel Papers, 1938-200613