- Frederick E. Kredel, M.D. Papers, 1925-19804
- Hasell Family Papers, 1803 - 18844
- J. Marion Sims Letters4
- James Kershaw papers, 1786-18254
- Millicent E. Brown Papers, 1949 - 20034
- Pringle-Garden Family Papers, 1701-18824
- Sandy Island Plantation Journals/Almanacs, 1792-17984
- W.P.A. Inventories of Church Archives in South Carolina, 1937-19394
- William Tennent III Journal and Album4
- American Federation of Musicians Local 502 records, 1911-19143
- Angelica Singleton Van Buren Collection3
- Charleston Year Book, 19363
- Colleton County Memorial Library Bookmobile History3
- Confederate Military Correspondence3
- Delbert Claire Brandt Collection3
- Ethelyn Murray Parker Papers3
- Harry and William Birch Collection3
- Horlbeck Brothers Records, 1824-18603
- John P. Berry Papers, 1844-18973
- Martha Elizabeth Cunningham Monteith Collection3