- Elizabeth W. Allston Pringle Family Papers, 1861-19262
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)2
- Friendly Moralist Society Records, 1841-18562
- Helen Evangeline Banks Harrison papers (circa 1850 - 1985)2
- Historic Southern Naturalists
2
- James W. Miles Papers, ca. 1840-18752
- John McCray Papers, 1932-19602
- Letters to Jonathan Lucas, 17962
- Martha Puckmire letters of guardianship and apprentices' indenture, 18522
- Micajah Adolphus Clark Journals, 1847-18572
- Miriam DeCosta Seabrook and Herbert U. Seabrook Papers, 1882-19952
- Philip Simmons Collection2
- Phillips Family Papers2
- Primary Sources for K-12, Pilot Project2
- Richard L. Walker: In His Own Words2
- Robert Heriot Correspondence, 17812
- South Carolina Library Association Digital Collection2
- South Caroliniana Library Map Collection2
- Sporting Journal of Maxcy Gregg2
- Stoney Family Papers, 1775-19492