- Ragsdale Family Papers, 1844-ca.192010
- 2nd South Carolina Regiment Records, 1778-17799
- Books and Pamphlets9
- Glover Family Papers, 1729-ca.19559
- John C. Calhoun Papers, 1782-18509
- MUSC College of Dental Medicine Oral History Project, 20119
- South Carolina Historical Society Manuscripts9
- Esau Jenkins Papers, 1963-20038
- Middleton Papers, 1775-18158
- Muster Roll and Orders to the Commissary, 1772-17818
- President's Reports to the Board of Trustees8
- Ravenel Family Papers, 1695-19258
- Records of the Bricklayers, Masons and Plasterers International Union of America, 1950-19558
- Records of the Church of the Holy Cross, 1788-19428
- Waring Manuscript8
- Daily reports, 1863 Dec. 17-237
- Historical and Governing Records, 1841-19257
- James Kershaw Papers, 1786-18257
- John Henry McCray Papers, 1929-19897
- L. Mendel Rivers Papers, 1940-19627