Collection
- Delbert Claire Brandt Collection91
- Diamond Fields of South Africa: Memoirs, Mines, and Minerals7
- Diaries110
- Diary and Account Book of Rene Ravenel and Henry Ravenel, 1731-186032
- Digital Collection (Relation)1
- Dirleton Plantation Memorandum Book, 1859-19281
- Documentation for the People: Celebrating 125 Years as a Federal Depository Library15
- Dorchester: Our Homes - Our people - Our Story4
- Drayton Family Papers, 1837-186918
- Drayton Papers, 1701-200426
- Due West Female College Photograph Collection31
- E. E. Burson Photograph Collection250
- E.D.E.N. Southworth Collection44
- E.T. Start Photograph Collection213
- Early California Scrapbooks1
- Early History of Columbia College144
- Edgewood School Yearbooks6
- Edisto Island Historic Preservation Society Oral Histories3
- Edmondston-Alston Family Letters and Paper Materials, 1782-19191,253
- Edmondston-Alston Photograph Collection2