- Camilla Urso Collection59
- Camp St. Mary Records, 1931-1997, undated2
- Captain William Boykin Lyles Estate Record Ledger1
- Carl Julien Collection1,471
- Carl Sandburg's Collection of Stereographs14
- Carolina Bands Collection66
- Carolina Students' Handbook, 1920-19401
- Carolyn Browne Hodges Scrapbook1
- Carver High School20
- Catalog of the Collections of Minerals in the College of South Carolina2
- Catherine M. McCottry, M.D. Papers12
- Center for Women's and Gender Studies 20th Anniversary Poster Collection38
- Central High School Yearbooks7
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Cross Collection of Buchenwald Concentration Camp Photographs, 194518
- Charles Family Civil War Era Letters 2
- Charles Fraser's Sketchbook, 1796-1805115
- Charles Henry Meltzer Papers, 1839-19405
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,613
- Charles Stuart Vedder Papers3