- WPA Federal Writers' Project on African American Life in South Carolina2
- William Henry Jackson Photochrom Collection, 1898-19052
- William Jennings Bryan Dorn: In His Own Words2
- YWCA of Greater Charleston, Inc., Records, 1906 - 20072
- A. Wolfe Davidson, The Man Behind the Sculpture1
- Allston Family Papers, 1730-19011
- Andrews Museum Collection1
- Avery Normal Institute1
- Beautifying and Improving Greenville, S.C.1
- Bernice Robinson Papers, 1920-19891
- Burton L. Padoll Papers, 1957-20091
- Caines Family Photograph Collection1
- Call for Change1
- Carolina Bands Collection1
- Charles Fraser's Sketchbook, 1796-18051
- City of Charleston Collection1
- Cleveland Family Collection 1
- Color slides of South Carolina State Parks1
- Congaree Photographic Prints1
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)1