- Early History of Columbia College97
- Edmondston-Alston Family Letters and Paper Materials, 1782-191964
- Equal Rights Amendment19
- Erastus W. Everson Papers, 1837-18933
- Esau Jenkins Papers, 1963-2003143
- Ethelyn Murray Parker Papers34
- Eugene C. Hunt Papers, 1834 - 199486
- Fox Movietone News: The War Years204
- Francis Peyre Porcher Papers1
- Frederick E. Kredel, M.D. Papers, 1925-19801
- Fritz Hollings: In His Own Words4
- Gertrude Sanford Legendre Papers, 1844-19961
- Greenville City Codes4
- Gussie Johnson Papers, 1940-200014
- Hampstead and Bethany Cemeteries58
- Helen Evangeline Banks Harrison papers (circa 1850 - 1985)18
- Historic Meeting Minutes of Mullins, South Carolina740
- Historical and Governing Records, 1841-192510
- History of the University of South Carolina School of Medicine - Columbia12
- Hunger in America62