- Isaiah Bennett Papers, ca. 1932-200257
- South Carolina and the Civil War57
- Langdon Cheves Papers, 1777-186456
- Thomas Pinckney papers, ca. 1790-ca. 1825.52
- College of Charleston Magazines48
- Drayton Family Papers, 1837-186946
- Horace Gilbert Smithy, Jr., M.D. Papers40
- Kahal Kadosh Beth Elohim Congregation Records33
- Charleston Dental Association Records30
- Laura Bragg Papers25
- John F. Riley papers, 1884-1921 (bulk 1884-1895)24
- Slave Records in the Discrete Manuscript Collection22
- William Ancrum Letter Book and Account Book22
- Historical and Governing Records, 1841-192521
- Diary of Charles Drayton I, 1791-179820
- Mary Motte Alston Pringle Receipt Book19
- Allston Family Papers, 1730-190118
- Buildings and Properties, 1841-193718
- City Year Books for Charleston, South Carolina, 1880-195118
- Mary Lamboll Thomas Beach Papers, 1822-189018