- James Simons Papers, 1832-18798
- Lazarus and Hirsch Family Papers8
- Records of the Bricklayers, Masons and Plasterers International Union of America, 1950-19558
- Reverend Alexander Glennie Meteorological Observations, 1834-18808
- Waring Manuscript8
- Daily reports, 1863 Dec. 17-237
- Drayton Papers, 1701-20047
- Glover Family Papers, 1729-ca.19557
- Lucas-Porcher Family Papers, 1827-19727
- Records of Charleston fire companies, 1862-18647
- Isaac Harby Family Papers6
- Malloy Family Papers, 1861-19076
- The Calvin Shedd Papers, 1862 - 18646
- Zionist Organization of America Records6
- Marguerite Andell Collection, 1919-19465
- Phillis Wheatley Literary and Social Club Papers5
- Warren Hubert Moise Letters, 1933-19395
- Ale boycott records, 18904
- Berkeley County (S.C.) Memories4
- Eighteenth & Nineteenth Century Correspondence Collection4