- Henry Laurens papers, 1747-18602
- L. Mendel Rivers Papers, 1940-19622
- Phillips Family Papers2
- South Carolina Dental Association Records2
- Strom Thurmond Collection, Mss 1002
- The Citadel Alumni War Veterans Collection2
- William Moultrie Correspondence, 17812
- 2nd South Carolina Regiment Order Book and Related Records, 1777-ca. 19291
- Advertisement for Madame Togno's School for Young Ladies, ca. 18551
- Armstrong Family Papers, 1900-19301
- Avery Normal Institute1
- Berkeley County (S.C) Memories1
- Catherine M. McCottry, M.D. Papers1
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Fraser Book of Precedents, 1800-18191
- Charleston Bible Society Records, 1815-20101
- Charleston Museum Collection1
- Charleston and Savannah Railroad Records1
- Circular letter, 1783 April 2 – From Guerard, Benjamin1
- Cora Godfrey Justice Family Papers, 1816-19871