- Drayton family papers, 1837-18691
- Eliza Pinckney Receipt Book1
- Esau Jenkins Papers, 1963-20031
- Extract from the minutes of the monthly meeting, 1887 - Mechanics' Union No. 11
- Fairfield County Manuscript Collection1
- Family Bible Records1
- Frank Fisher Notes, 1882-19021
- General Orders of William Moultrie and Benjamin Lincoln, 17791
- Halley's Comet Project, 1985-19861
- Harby Academy Cashbook1
- Hebrew Benevolent Society Papers1
- Henry Laurens Account Book, 1766-17331
- History of the Charleston Fire Department, 19531
- Holloway Family Collection1
- Invoice of rice sales for Anthony Clarkson, 1762 Oct. 301
- Irish Volunteers Company records, 1798-19291
- J. F. R. Papers, 1849-18551
- Journal of Samuel Wilson, 18541
- Langdon Cheves III Hunting Notes & Art1
- Levi L. Kibler Letters Received1