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Collection
- Allston Family Papers, 1730-190139
- American Revolution Records in the Discrete Manuscript Collection3
- Ball Family Papers, 1631-1895481
- Charleston Bible Society Records, 1815-20101
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)94
- Cohen, Emanuel, Moses, Seixas Family Papers1
- Collection of Bishop Patrick Lynch Confederate Commissioner Papers, 1864-18655
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)26
- Cranston Family Papers, 1822-195916
- DeBerniere Family Papers, 1790-1930 (bulk 1790-1860)1
- Drayton Family Papers, 1837-18692
- Edmondston-Alston Family Letters and Paper Materials, 1782-191912
- Eighteenth & Nineteenth Century Correspondence Collection2
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)2
- Henry Laurens papers, 1747-18605
- Isaac Harby Family Papers1
- Langdon Cheves Papers, 1777-186451
- Letter to Harriott Horry, ca. 17801
- Lucas-Porcher Family Papers, 1827-19721
- Manigault Family Papers, 1685-19711