- Chesnut Family Papers, 1741-19004
- Cote Bas and Mepkin Plantations Journals, 1865-18774
- Eighteenth & Nineteenth Century Correspondence Collection4
- Frederick E. Kredel, M.D. Papers, 1925-19804
- Hasell Family Papers, 1803 - 18844
- J. Marion Sims Letters4
- James Kershaw papers, 1786-18254
- Millicent E. Brown Papers, 1949 - 20034
- Nathaniel Russell Middleton Papers, 1823-18814
- Pringle-Garden Family Papers, 1701-18824
- Sandy Island Plantation Journals/Almanacs, 1792-17984
- W.P.A. Inventories of Church Archives in South Carolina, 1937-19394
- American Federation of Musicians Local 502 records, 1911-19143
- Angelica Singleton Van Buren Collection3
- Charleston Slave Passes3
- Charleston Year Book, 19363
- Colleton County Memorial Library Bookmobile History3
- Confederate Military Correspondence3
- Delbert Claire Brandt Collection3
- Ethelyn Murray Parker Papers3