- Harry and William Birch Collection3
- Horlbeck Brothers Records, 1824-18603
- John P. Berry Papers, 1844-18973
- Martha Elizabeth Cunningham Monteith Collection3
- Marx E. Cohen Plantation Records, 1840-18683
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)3
- O. H. Wienges World War II Collection3
- Primary Sources for K-12, Pilot Project3
- Rose Hill Plantation Time Books, 18783
- Senator Burnet R. Maybank Papers, 1914-19733
- South Caroliniana Library Map Collection3
- Temple Sinai (Sumter, S.C.) Records3
- UDC South Carolina Chapter3
- Vanderhorst Family Papers, 1689-19423
- Account Books of Benjamin Perry's Wards, 1841-18642
- Alexander Inglis Papers, 1782-1811 (bulk 1800-1802)2
- Berkeley County (S.C) Memories2
- Catalog of the Collections of Minerals in the College of South Carolina2
- Charleston City Directories2
- Charleston Iron Works records, 19072