- Catherine M. McCottry, M.D. Papers1
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Fraser Book of Precedents, 1800-18191
- Charleston Bible Society Records, 1815-20101
- Charleston Museum Collection1
- Charleston and Savannah Railroad Records1
- Church Session Books Excerpts, 1816-1901.1
- Circular letter, 1783 April 2 – From Guerard, Benjamin1
- Cleveland Family Collection 1
- Colleton County Memorial Library Minute Books and Ledgers1
- Congarees Store Account Book1
- DeBerniere Family Papers, 1790-1930 (bulk 1790-1860)1
- Dirleton Plantation Memorandum Book, 1859-19281
- Drayton family papers, 1837-18691
- Eliza Pinckney Receipt Book1
- Ellinor P. Gadsden Family Papers, 1848-19701
- Extract from the minutes of the monthly meeting, 1887 - Mechanics' Union No. 11
- Fairfield Plantation Papers1
- Frank Fisher Notes, 1882-19021
- Fraser Family Papers, 1755-18721