- Edwin Hughes Collection371
- William Drayton Rutherford Papers339
- Mulberry Plantation Journals, 1853-1908 (bulk 1853-1889)295
- Inventory of S.C. Church Archives284
- Brandon Mill Ledger280
- Allston Family Papers, 1730-1901247
- Henry William Ravenel Papers, 1739-1935242
- Wilkinson-Keith Family Papers241
- Henry Laurens papers, 1747-1860239
- South Carolina and the Civil War239
- 4th South Carolina Regiment Order Book235
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera229
- William Ancrum Letter Book and Account Book220
- Papers of the Cox and Chesnut Families, 1792-1858212
- John Henry McCray papers, 1929-1989211
- Grimke family papers, 1678-1977199
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-1995190
- Mary Motte Alston Pringle Receipt Book155
- Modjeska Simkins Papers, 1909-1992155
- YWCA of Greater Charleston, Inc., Records, 1906 - 2007151