- John Henry McCray papers, 1929-1989203
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-1995190
- Barnwell Family Papers179
- Modjeska Simkins Papers, 1909-1992155
- YWCA of Greater Charleston, Inc., Records, 1906 - 2007151
- Langdon Cheves Papers, 1777-1864142
- The Marian Bruce Logan Collection of Civil Rights Activism, Personal Correspondence, 1945-1989135
- William ("Bill") Saunders Papers, circa 1950 - 2004124
- St. Andrew's Society of Charleston Records, 1729-2001118
- Rabbi Jacob S. Raisin Papers108
- James Glen Papers102
- Eugene Avery Adams papers, 1892-196897
- Family Bible Records96
- Historic Southern Naturalists96
- Slave Records in the Discrete Manuscript Collection89
- Fairfield County Manuscript Collection87
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections82
- Medical Society of South Carolina Digital Collections80
- Flagg Family Papers, 1832-192674
- Armstrong Family Papers, 1900-193071