- Langdon Cheves Papers, 1777-1864142
- The Marian Bruce Logan Collection of Civil Rights Activism, Personal Correspondence, 1945-1989135
- St. Paul's Episcopal Church records, 1819-1971134
- William ("Bill") Saunders Papers, circa 1950 - 2004124
- St. Andrew's Society of Charleston Records, 1729-2001118
- Mills Family of Greenville114
- Bernice Robinson Papers, 1920-1989111
- City of Charleston Collection111
- Rabbi Jacob S. Raisin Papers109
- William Howell Ledger108
- James Glen Papers102
- Pierrine Smith Byrd Papers, 1919-1991102
- Gabriel Manigault Journal, 1774-1784101
- Septima P. Clark Papers, ca. 1910-ca. 199098
- Eugene Avery Adams papers, 1892-196897
- Family Bible Records97
- Historic Southern Naturalists96
- Alexander McBeth Store Ledger, 179494
- 2nd South Carolina Regiment Paybook, 177591
- Board of Trustees Annual Reports91