- Charleston Firefighters Rosters, 1862-186416
- Charleston Iron Works records, 19072
- Charleston Museum Collection1
- Charleston Museum Collection of Revolutionary War Letters70
- Charleston Slave Passes3
- Charleston Year Book, 19363
- Charleston and Savannah Railroad Records1
- Chesnut Family Papers, 1741-19004
- Chester County Historical Collection, 1739-199722
- Church Session Books Excerpts, 1816-1901.1
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)538
- Circular letter, 1783 April 2 – From Guerard, Benjamin1
- City Year Books for Charleston, South Carolina, 1880-195118
- City of Charleston Collection111
- Civic Services Committee Papers1,139
- Clemson University Class of 193936
- Cleveland Family Collection 1
- Cleveland L. Sellers, Jr. Papers, 1934 - 200366
- Coffin Point Plantation Journals, 1800-18165
- Cohen, Emanuel, Moses, Seixas Family Papers2