- Fairfield County Manuscript Collection87
- Fairfield Plantation Papers1
- Family Bible Records97
- Flagg Family Papers, 1832-192674
- Francis Peyre Porcher Papers69
- Frank Fisher Notes, 1882-19021
- Fraser Family Papers, 1755-18721
- Frederick E. Kredel, M.D. Papers, 1925-19804
- Friendly Moralist Society Records, 1841-18562
- Fritz Hollings: In His Own Words1
- G. Ross Roy Collection of Burnsiana and Scottish Literature27
- Gabriel Manigault Journal, 1774-1784101
- Gaillard Family Papers, 1758-19011
- Gaillard Family Papers, 1795-18501
- General Orders of William Moultrie and Benjamin Lincoln, 17791
- George Chicken Journal, 1715-17161
- Gertrude Sanford Legendre Papers, 1844-1996664
- Glenn Drayton journal, 1814-18641
- Glover Family Papers, 1729-ca.19559
- Gooch Family Papers, 1754-194744