- Historic Southern Naturalists
2
- Historical and Governing Records, 1841-192521
- History of the Charleston Fire Department, 19531
- History of the University of South Carolina School of Medicine - Columbia1
- Holloway Family Collection1
- Horace Gilbert Smithy, Jr., M.D. Papers40
- Horlbeck Brothers Records, 1824-18603
- Huger Family Papers, 1795-18971
- Hunger in America1
- Hurricane Hugo Oral History Collection, 200911
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections82
- Inventory of S.C. Church Archives284
- Invoice of rice sales for Anthony Clarkson, 1762 Oct. 301
- Irish Volunteers Company records, 1798-19291
- Isaac Harby Family Papers6
- Isaac Hayne Journal: Register, ca. 1764-17811
- Isabella Sarah Porcher Plantation Prescription Book1
- Isaiah Bennett Papers, ca. 1932-200257
- Isaiah DeQuincey Newman Papers1
- J. Arthur Brown Papers, 1937 - 198813