- Simons & Lapham Architectural Drawings, 1919-195214
- Small-Whaley Family Papers, 1796-19941
- South Carolina Inter-State and West Indian Exposition, 1901-190212
- South Carolina LGBTQ Oral Histories, Archives, and Outreach69
- St. Andrew's Society of Charleston Records, 1729-2001118
- Temple Sinai (Sumter, S.C.) Records106
- The Black Whale, by Gabriel E. Manigault1
- The Joseph Mordecai Hirschmann Collection197
- The Lithographs of Prentiss Taylor: a Catalogue Raisonne16
- The Thomas Haythe Rare Book Collection2
- Thomas J. Tobias papers, ca. 1790-197064
- Vera Nathans Semel Papers, 1830-198518
- Vincent P. Lannie Collection, 1733-19745
- Warren Hubert Moise Letters, 1933-193915
- Weston Family Papers, 1764-18552
- Wilkinson-Keith Family Papers242
- William A. Rosenthall Judaica Collection - Postcards3,831
- William A. Rosenthall Judaica Collection - Prints and Photographs1,588
- William Henry Jackson Photochrom Collection, 1898-190582
- William M. Halsey and Corrie McCallum Paintings12