- Wilkinson-Keith Family Papers10
- Barnwell Family Papers9
- Septima P. Clark Papers, ca. 1910-ca. 19909
- U.S. military in Fort Moultrie, South Carolina, 1900-19459
- Allston Family Papers, 1730-19018
- James Simons Papers, 1832-18798
- WPA Federal Writers' Project on African American Life in South Carolina8
- Daily reports, 1863 Dec. 17-237
- Heyward and Ferguson Family Papers, 1806-19237
- Lucas-Porcher Family Papers, 1827-19727
- Civic Services Committee Papers6
- Color Slides from Fort Sumter National Historical Monument6
- Smith and Wells Papers, 1856-19076
- Bettie La Barbe Postcard Collection5
- Civil War and Reconstruction Era Stereoscope Photographs of the Port Royal Region5
- Lynch Family Letters, 1858-18665
- The Calvin Shedd Papers, 1862 - 18645
- Lowcountry Fish and Shrimp Nets4
- Phillips Family Papers4
- Sullivan's Island Oral History Collection4