- YWCA of Greater Charleston, Inc., Records, 1906 - 20071,404
- Georgetown County Digital Library1,373
- John Shaw Billings Scrapbook1,371
- South Carolina State Parks Civilian Conservation Corps Architectural Plans1,362
- Sheet music from the Joseph M. Bruccoli Great War Collection1,250
- Georgetown County Historical Survey1,216
- South Carolina Historical Records Survey Collection1,182
- E. Don Herd Photograph Collection1,112
- South Caroliniana Library Map Collection1,103
- Harry and William Birch Collection1,098
- Works Progress Administration photograph collection: South Carolina places : 193u-194u.1,069
- College of Charleston Buildings and Grounds Photograph Collection1,059
- William Lynch Postcard Collection1,017
- Home Movies from Moving Image Research Collections1,006
- Photos from the Records of The Historic Preservation Planner, BCD-COG985
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library940
- Greenwood Mills Photograph Collection919
- Specimens from the Bob Campbell Geology Museum897
- John Henry McCray papers, 1929-1989893
- William ("Bill") Saunders Papers, circa 1950 - 2004891