- Horace Gilbert Smithy, Jr., M.D. Papers152
- The State Newspaper Photograph Archive151
- South Carolina State Parks Civilian Conservation Corps Architectural Plans143
- South Caroliniana Library Map Collection142
- Richard Furman and James C. Furman Collection141
- St. Andrew's Society of Charleston Records, 1729-2001117
- The South Carolina Artifact Documentation Project116
- Charles Fraser's Sketchbook, 1796-1805114
- Burton L. Padoll Papers, 1957-2009110
- Temple Sinai (Sumter, S.C.) Records106
- James Glen Papers102
- George LaGrange Cook Photograph Collection99
- Rabbi Jacob S. Raisin Papers87
- Mamie E. Garvin Fields Papers, 1894 - 198785
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192083
- Diaries80
- Medical Society of South Carolina Digital Collections80
- Georgetown County Digital Library77
- Jewish Heritage Collection Oral Histories76
- Francis Peyre Porcher Papers75