Collection
- South Carolina Baptist Church Records1
- South Carolina Hospital Postcards1
- South Carolina Library Buildings Collection1
- South Carolina Medical Association Oral History Collection1
- South Carolina and World War II1
- Stereographic Views of South Carolina1
- Stokes Grocery Store Ledger1
- Strom Thurmond Collection, Mss 1001
- Temple Sinai (Sumter, S.C.) Records1
- The 2015 South Carolina Flood Oral History Collection1
- The Black Whale, by Gabriel E. Manigault1
- The Citadel and the American Civil War1
- The James Poyas Daybook1
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera1
- The Menu Project1
- The Thomas Haythe Rare Book Collection1
- Thomas Pinckney papers, ca. 1790-ca. 1825.1
- Transportation1
- USC School of Medicine Digital Collections1
- University of South Carolina Aiken Photograph Collection, 1961-20111