- Andrews Museum Collection5
- Cleveland L. Sellers, Jr. Papers, 1934 - 20035
- Coffin Point Plantation Journals, 1800-18165
- Congaree Photographic Prints5
- E.D.E.N. Southworth Collection5
- Georgetown Postcard Collection5
- Henry William Ravenel, Plants and Planter5
- Lanny and Sidney Palmer Collection5
- M. Hayes Mizell Papers5
- Richland Library Archives5
- Robert B. Ariail Collection of Historical Astronomy5
- Slave Records in the Discrete Manuscript Collection5
- William ("Bill") Saunders Papers, circa 1950 - 20045
- William Ancrum Letter Book and Account Book5
- YWCA of Greater Charleston, Inc., Records, 1906 - 20075
- A. Wolfe Davidson Photographs4
- Albert Simons Papers, 1908-19774
- Charleston Naval Shipyard Photographs4
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)4
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)4