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Collection
- Adger Family Papers, 1813-19321
- Agricultural Society of South Carolina Visual Materials3
- Ball Family Papers, 1631-18951
- City Engineers's Plat Book, 1671-19512
- Edmondston-Alston Family Letters and Paper Materials, 1782-19191
- G. Ross Roy Collection of Burnsiana and Scottish Literature4
- Gourdin Family Collection, 1707-19031
- Grimke family papers, 1678-19772
- Historic Southern Naturalists7
- Literary Annuals4
- Lutheran Theological Southern Seminary Collection1
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19202
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library5
- Richard Furman and James C. Furman Collection1
- Robert B. Ariail Collection of Historical Astronomy1
- Slave Records in the Discrete Manuscript Collection1
- South Carolina Baptist Church Records44
- South Carolina Fall Line Collection2
- The Development of the Printed Page: 150 Examples of Handpress Printing and its Antecedents, ca. 1200 to 19371
- The South Carolina Artifact Documentation Project1