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Collection
- Allston Family Papers, 1730-19014
- Bacot Family Papers, 1752-19731
- Ball Family Papers, 1631-18951
- Chester County Historical Collection, 1739-19975
- City Engineers's Plat Book, 1671-195111
- Course Catalogs1
- Hemrick Nathan Salley Family Sheet Music2
- Historic Southern Naturalists2
- History of Education in America1
- John McCrady Plats and Deeds Collection1
- Journal of Samuel Wilson, 18541
- Langdon Cheves Papers, 1777-18641
- McBee Sons & Company Store Ledger Book, 1846-18611
- Medical College Expansion Program Lantern Slides, 1954-19741
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19204
- Pringle-Garden Family Papers, 1701-18821
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library1
- Ron Swain Map Collection3
- Slave Records in the Discrete Manuscript Collection2
- South Carolina Baptist Church Records87