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Collection
- Adger Family Papers, 1813-19321
- Advertisement for Madame Togno's School for Young Ladies, ca. 18551
- Allston Family Papers, 1730-19012
- Bowman Family Papers, 1835-18921
- Chester County Historical Collection, 1739-19972
- City Engineers's Plat Book, 1671-195113
- Civil War Era Maps1
- Cloe T.W. Greene Diaries1
- Course Catalogs1
- Diaries1
- Documentation for the People: Celebrating 125 Years as a Federal Depository Library1
- Drayton Family Papers, 1837-18691
- E.D.E.N. Southworth Collection1
- Hampstead and Bethany Cemeteries2
- Henry William Ravenel: Plants & Planter2
- Historic Southern Naturalists7
- Literary Annuals1
- Lucas-Porcher Family Papers, 1827-19721
- McBee Sons & Company Store Ledger Book, 1846-18611
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19204