- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- Hampstead and Bethany Cemeteries1
- Hemrick Nathan Salley Family Sheet Music2
- Henry William Ravenel: Plants & Planter1
- Heyward and Ferguson Family Papers, 1806-19231
- Historic Southern Naturalists6
- Historic Southern Naturalists
1
- Huger Family Papers, 1795-18971
- Hutson Lee Papers, 1858-18658
- John Shaw Billings Scrapbook1
- Langdon Cheves Papers, 1777-18642
- Mary Motte Alston Pringle Receipt Book1
- McBee Sons & Company Store Ledger Book, 1846-18611
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19205
- Mulberry Plantation Journals, 1853-1908 (bulk 1853-1889)1
- Nathaniel Russell Middleton Papers, 1823-18811
- Primary Sources for K-12, Pilot Project1
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library19
- Richmond Plantation Journal, 1859-18601
- Robert B. Ariail Collection of Historical Astronomy1