- John R. Beaty Letters1
- Langdon Cheves III Hunting Notes & Art4
- Letters to Alfred Wardlaw, 1857-18622
- Mary Motte Alston Pringle Receipt Book1
- McBee Sons & Company Store Ledger Book, 1846-18611
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19204
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library5
- Ron Swain Map Collection4
- Slave Records in the Discrete Manuscript Collection5
- South Carolina Baptist Church Records91
- South Carolina Fall Line Collection1
- South Carolina Historical Society Manuscripts1
- South Carolina and the Civil War42
- South Caroliniana Library Map Collection16
- South Caroliniana Pamphlet Collection1
- St. Paul's Episcopal Church records, 1819-19711
- Stereographic Views of South Carolina1
- Summerville Museum and Research Center Pamphlet Collection1
- University of South Carolina Student Exams, 1854 - 19172
- Walter Pantovic Slavery and African American History Collection2