- Letters and Prints from the Campanella Collection of Giuseppe Garibaldi6
- Lucas-Porcher Family Papers, 1827-19721
- Lynch Family Letters, 1858-18662
- Mary Motte Alston Pringle Receipt Book2
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19203
- Mulberry Plantation Journals, 1853-1908 (bulk 1853-1889)38
- Nathaniel Russell House Museum Collection1
- Primary Sources for K-12, Pilot Project1
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library5
- Records of the Church of the Holy Cross, 1788-19423
- Ron Swain Map Collection1
- Slave Records in the Discrete Manuscript Collection1
- Smith and Wells Papers, 1856-19072
- South Carolina Baptist Church Records91
- South Carolina and the Civil War6
- South Caroliniana Library Map Collection7
- St. Paul's Episcopal Church records, 1819-19711
- Stereographic Views of South Carolina11
- Thomas Benton Brooks Papers3
- Ware Family Manuscripts1