- J. Marion Sims Letters1
- John Shaw Billings Scrapbook1
- MUSC College of Medicine Class Photos1
- Mary Motte Alston Pringle Receipt Book1
- Massenet First Edition Opera Scores1
- Midlands Memories1
- Midlands Memories 2
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19206
- Mulberry Plantation Journals, 1853-1908 (bulk 1853-1889)19
- One Man's Dream - William Plumer Jacobs and Clinton, South Carolina1
- Parish Records15
- Pearlstine-Strauss Family Papers1
- Phosphates in South Carolina, 1870-18901
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library5
- Reverend Alexander Glennie Meteorological Observations, 1834-18802
- Robert B. Ariail Collection of Historical Astronomy3
- Russell Maxey Photograph Collection3
- South Carolina Baptist Church Records83
- South Carolina Fall Line Collection5
- South Caroliniana Library Map Collection2