- Heyward and Ferguson Family Papers, 1806-19231
- Historic Southern Naturalists2
- Historical and Governing Records, 1841-19251
- Illustrated Newspaper Clippings, 1840-19171
- John Shaw Billings Scrapbook1
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19205
- Mulberry Plantation Journals, 1853-1908 (bulk 1853-1889)22
- One Man's Dream - William Plumer Jacobs and Clinton, South Carolina1
- Parish Records10
- Ron Swain Map Collection1
- South Carolina Baptist Church Records81
- South Caroliniana Library Map Collection2
- St. Paul's Episcopal Church records, 1819-19711
- Standard Federal (Columbia S.C.) Photograph Collection2
- Stereoscopic Photographs1
- The Bonneville Collection: 19th Century Images of Native Americans and Soldiers in the American Mid-West5
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera1
- The Zacharias Collection1
- Tin Pan Alley Sheet Music Collection1
- Ware Family Manuscripts2