- Illustrated Newspaper Clippings, 1840-19172
- Johannah Gold Collection1
- John F. Riley papers, 1884-1921 (bulk 1884-1895)1
- John Shaw Billings Scrapbook31
- Mayors of Columbia1
- Midlands Memories5
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19206
- Parish Records10
- Primary Sources for K-12, Pilot Project1
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library7
- Robert B. Ariail Collection of Historical Astronomy2
- Shakespeare First Folio Teaching Resources2
- South Carolina Baptist Church Records82
- South Carolina Fall Line Collection2
- South Carolina and the Civil War1
- South Caroliniana Library Map Collection8
- Spartanburg at the Dawn of the Twentieth Century1
- St. Paul's Episcopal Church records, 1819-19711
- The Bonneville Collection: 19th Century Images of Native Americans and Soldiers in the American Mid-West7
- USC School of Medicine Digital Collections1