- Historical and Governing Records, 1841-19258
- History of the University of South Carolina School of Medicine - Columbia12
- Hutson Lee Papers, 1858-186515
- Illustrated Newspaper Clippings, 1840-19174
- Isaiah Bennett Papers, ca. 1932-200224
- Isaiah DeQuincey Newman Papers11
- J. Arthur Brown Papers, 1937 - 1988303
- James E. Campbell papers, 1930-200993
- Kahal Kadosh Beth Elohim Congregation Records4
- L. Mendel Rivers Papers, 1940-196257
- Lanny and Sidney Palmer Collection17
- Lazarus and Hirsch Family Papers2
- Levi L. Kibler Letters Received1
- Lutheran Theological Southern Seminary Collection2
- Mamie E. Garvin Fields Papers, 1894 - 1987120
- Martha Elizabeth Cunningham Monteith Collection34
- Martha Elizabeth Cunningham Monteith Collection 1
- Medical University of South Carolina University Bulletins, 1878-2002182
- Mercantile Agency Reference Book of South Carolina1
- Middleton Papers, 1775-18154