- C. Wayne Weart Apothecary Trade Cards, 1870-1920301
- C. Wayne Weart Pharmacy History Collection32
- Caines Family Photograph Collection40
- Camilla Urso Collection13
- Camp St. Mary Records, 1931-1997, undated2
- Carolina Bands Collection9
- Catherine M. McCottry, M.D. Papers10
- Charles Cross Collection of Buchenwald Concentration Camp Photographs, 194518
- Charles Family Civil War Era Letters 2
- Charles Fraser's Sketchbook, 1796-1805115
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,613
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19953
- Charleston Earthquake 1886148
- Charleston Souvenir Books2
- Charlotte Kaminski Scrapbook Collection1
- Chibbaro Stereograph Collection: 186u-1997581
- Civil War and Reconstruction Era Stereoscope Photographs of the Port Royal Region106
- Clemson University Historical Images157
- Cleveland L. Sellers, Jr. Papers, 1934 - 200337
- Cohen, Emanuel, Moses, Seixas Family Papers18