- Georgetown County Museum Collection554
- Phosphate, Farms, & Family: The Donner Collection548
- Waring Historical Library Artifact Collection512
- Georgetown County Library Collection487
- From the Kitchen Drawer and Cupboard: The Jerred Metz Collection of Manufacturers' Recipe and Advertisement Booklets 1902-1950462
- YWCA of Greater Charleston, Inc., Records, 1906 - 2007443
- Pawleys Island Civic Association436
- History of the University of South Carolina School of Medicine - Columbia408
- University of South Carolina Buildings and Grounds407
- South Carolina Aerial Photograph Indexes, 1937-1989331
- South Carolina and the Spanish American War330
- South Carolina and World War II304
- C. Wayne Weart Apothecary Trade Cards, 1870-1920301
- The Lucille Hasell Culp Collection300
- South Carolina Library Buildings Collection278
- Septima P. Clark Papers, ca. 1910-ca. 1990257
- Anna D. Kelly Papers, 1930s - 1999254
- Berkeley County (S.C.) Memories246
- E. E. Burson Photograph Collection241
- Views of Columbia, S.C.236