- Circular letter, 1783 April 2 – From Guerard, Benjamin1
- City Year Books for Charleston, South Carolina, 1880-195118
- City of Charleston Collection111
- College of Charleston Magazines47
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)178
- Cora Godfrey Justice Family Papers, 1816-19871
- Cranston Family Papers, 1822-195916
- Daily reports, 1863 Dec. 17-237
- Drayton Papers, 1701-20042
- Edmondston-Alston Family Letters and Paper Materials, 1782-191921
- Eighteenth & Nineteenth Century Correspondence Collection2
- Eliza Pinckney Receipt Book1
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)2
- Esau Jenkins Papers, 1963-20031
- Ethelyn Murray Parker Papers2
- Extract from the minutes of the monthly meeting, 1887 - Mechanics' Union No. 11
- Fairfield County Manuscript Collection1
- Family Bible Records1
- Francis Peyre Porcher Papers69
- Frank Fisher Notes, 1882-19021