- Historical and Governing Records, 1841-19257
- Lucas-Porcher Family Papers, 1827-19727
- Records of Charleston fire companies, 1862-18647
- Isaac Harby Family Papers6
- Malloy Family Papers, 1861-19076
- The Calvin Shedd Papers, 1862 - 18646
- Marguerite Andell Collection, 1919-19465
- Phillis Wheatley Literary and Social Club Papers5
- Warren Hubert Moise Letters, 1933-19395
- Ale boycott records, 18904
- Berkeley County (S.C.) Memories4
- Frederick E. Kredel, M.D. Papers, 1925-19804
- J. Marion Sims Letters4
- American Federation of Musicians Local 502 records, 1911-19143
- Bowman Family Papers, 1835-18923
- Horlbeck Brothers Records, 1824-18603
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)3
- Sarah Campbell Allan, M.D. Papers 1895-19523
- Temple Sinai (Sumter, S.C.) Records3
- Charleston City Directories2