- Grimke family papers, 1678-1977198
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-1995190
- Modjeska Simkins Papers, 1909-1992155
- YWCA of Greater Charleston, Inc., Records, 1906 - 2007151
- Langdon Cheves Papers, 1777-1864142
- The Marian Bruce Logan Collection of Civil Rights Activism, Personal Correspondence, 1945-1989135
- St. Paul's Episcopal Church records, 1819-1971134
- William ("Bill") Saunders Papers, circa 1950 - 2004124
- St. Andrew's Society of Charleston Records, 1729-2001118
- Mills Family of Greenville114
- Bernice Robinson Papers, 1920-1989111
- Rabbi Jacob S. Raisin Papers109
- James Glen Papers102
- Septima P. Clark Papers, ca. 1910-ca. 199098
- Family Bible Records96
- Historic Southern Naturalists95
- Board of Trustees Annual Reports91
- Slave Records in the Discrete Manuscript Collection89
- Halley's Comet Project, 1985-198688
- Fairfield County Manuscript Collection87