- Mills Family of Greenville114
- Bernice Robinson Papers, 1920-1989111
- City of Charleston Collection111
- Rabbi Jacob S. Raisin Papers109
- William Howell Ledger108
- James Glen Papers102
- Septima P. Clark Papers, ca. 1910-ca. 199098
- Family Bible Records97
- Gabriel Manigault Journal, 1774-178496
- Historic Southern Naturalists95
- Alexander McBeth Store Ledger, 179494
- 2nd South Carolina Regiment Paybook, 177591
- Board of Trustees Annual Reports91
- Halley's Comet Project, 1985-198688
- Fairfield County Manuscript Collection87
- Slave Records in the Discrete Manuscript Collection86
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections82
- Medical Society of South Carolina Digital Collections80
- Eugene Avery Adams papers, 1892-196877
- Flagg Family Papers, 1832-192674