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Collection
- The American Revolution in South Carolina136
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera130
- Gertrude Sanford Legendre Papers, 1844-199673
- Ball Family Papers, 1631-189544
- Henry William Ravenel, Plants and Planter37
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)10
- Colin J. McRae Papers, Huse Audit Series9
- Edmondston-Alston Family Letters and Paper Materials, 1782-19197
- Gabriel Manigault Journal, 1774-17847
- James Glen Papers7
- Grimke family papers, 1678-19774
- Halley's Comet Project, 1985-19864
- Papers of the Cox and Chesnut Families, 1792-18584
- Henry Laurens papers, 1747-18603
- Family Bible Records2
- Francis Peyre Porcher Papers2
- Slave Records in the Discrete Manuscript Collection2
- American Revolution Records in the Discrete Manuscript Collection1
- Edwin Hughes Collection1
- Fairfield County Manuscript Collection1