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Collection
- Ball Family Papers, 1631-189589
- Henry William Ravenel, Plants and Planter45
- The American Revolution in South Carolina18
- Samuel Badger Papers, 1767-17739
- South Carolina and the Civil War4
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera4
- Modjeska Simkins: In Her Own Words3
- Edmondston-Alston Family Letters and Paper Materials, 1782-19192
- Gabriel Manigault Journal, 1774-17842
- Mills Family of Greenville2
- Walter Pantovic Slavery and African American History Collection2
- Allston Family Papers, 1730-19011
- Cleveland L. Sellers, Jr. Papers, 1934 - 20031
- Erastus W. Everson Papers, 1837-18931
- Fairfield County Manuscript Collection1
- Grimke family papers, 1678-19771
- Halley's Comet Project, 1985-19861
- Historic Southern Naturalists1
- Samuel Pope, Seaman's Protection Certificate, 18201
- William Drayton Rutherford Papers1