- Ball Family Papers, 1631-1895206
- Photographic Record of the Cooper River Bridge202
- The State Newspaper Photograph Archive184
- Medical University of South Carolina University Bulletins, 1878-2002182
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)178
- The Charleston Oral History Program160
- Charleston Earthquake 1886152
- Horace Gilbert Smithy, Jr., M.D. Papers152
- South Carolina State Parks Civilian Conservation Corps Architectural Plans143
- South Caroliniana Library Map Collection142
- Richard Furman and James C. Furman Collection141
- Albert Sottile, Jr. Papers125
- St. Andrew's Society of Charleston Records, 1729-2001117
- The South Carolina Artifact Documentation Project116
- Charles Fraser's Sketchbook, 1796-1805114
- City of Charleston Collection113
- Burton L. Padoll Papers, 1957-2009110
- Temple Sinai (Sumter, S.C.) Records106
- James Glen Papers102
- George LaGrange Cook Photograph Collection99